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Biopsy of the kidney determines the type of lupus nephritis, the severity of inflammation and the degree of fibrosis (scarring). Inflammation is potentially reversible with therapy, whereas scarring is not. The information is used to guide therapy. The International Society of Nephrology/American Society of Nephrology divides the pathologic classification of lupus nephritis into major subtypes. Types I and II represent mild disease, where specific treatment is not required. By contrast, Types III and IV represent severe inflammatory disease with likely progression to end stage kidney disease if untreated. Type V in a non-inflammatory type disease (requiring treatment) and Type VI represents chronic, irreversible, scarring approaching near end stage disease. In Mauritius, most lupus patients are diagnosed with Lupus Nephritis and may have classifications of Type IV to Type VI.